Novo Nordisk Semaglutide/cardiovascular outcomes SELECT Trial Results (NVO + see also LLY)

“Previously reported top-line results showed semaglutide 2.4 mg delivered a statistically significant 20% risk reduction in MACE over a period of up to five years versus placebo (HR: 0.80; 95% confidence interval: 0.72; 0.90, p<0.001). Today’s findings showed that risk reductions in MACE were achieved regardless of age, gender, ethnicity and starting body mass index (BMI).1 The results also demonstrated that the beneficial effects in MACE risk reduction were evident soon after treatment initiation, suggesting an effect that is more rapid than what would be expected if the cardiovascular effects were entirely mediated with the effects of semaglutide 2.4 mg on body weight reduction.1 This suggests that weight loss alone may not fully explain the benefits of semaglutide 2.4 mg in reducing the risk of MACE.1″

Full: https://www.globenewswire.com/news-release/2023/11/11/2778596/0/en/Novo-Nordisk-A-S-Semaglutide-2-4-mg-Wegovy-cardiovascular-outcomes-data-presented-at-American-Heart-Association-Scientific-Sessions-and-simultaneously-published-in-New-England-Jour.html