From -65% to -43%, still far from OK zone. What was the worst paper loss you experienced? How did it go in the end?

Some time ago I posted about my situation. My portfolio is packed with future “potential” stocks, meme-like (CLOV, SPCE, BB..), etc.
Since then, I have been able to recover 22% although I am still far from the end of the tunnel. In the mean time, I realised almost 10k of real profits.

I am curious about your experiences and what would be your advice?
Shall I keep waiting for better times (I can do it even up to 5 years) or shall I do something differently?